Bladder Cancer

Pembrolizumab Shows Promise for BCG-Unresponsive Bladder Cancer

Pembrolizumab Shows Promise for BCG-Unresponsive Bladder Cancer

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Pembrolizumab, a PD-1 inhibitor, demonstrated antitumor activity in patients with high-risk BCG-unresponsive carcinoma in situ.

Radical Cystectomy Superior to Trimodal Therapy for Muscle-Invasive Bladder Cancer

Radical Cystectomy Superior to Trimodal Therapy for Muscle-Invasive Bladder Cancer

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Trimodal therapy for patients with muscle-invasive bladder cancer is associated with worse cancer-specific and overall survival and higher costs compared with radical cystectomy.

Radiation, Chemotherapy Not Beneficial in Localized Upper Tract Urothelial Carcinoma

Radiation, Chemotherapy Not Beneficial in Localized Upper Tract Urothelial Carcinoma

In a study of patients receiving non-surgical treatment for localized upper tract urothelial carcinoma, radiation or chemotherapy provided no overall survival benefit.

Squamous MIBC Histology Predicts Worse Survival

Squamous MIBC Histology Predicts Worse Survival

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Squamous cell carcinoma is associated with a 79% increased risk of death compared with urothelial carcinoma in patients with muscle-invasive bladder cancer, study finds.

Suicide Risk Up More Than 4-fold for Cancer Patients

Suicide Risk Up More Than 4-fold for Cancer Patients

Standardized mortality ratio highest for cancers of lung, head and neck, testes, bladder, Hodgkin lymphoma.

Global Demand for Bladder Cancer Treatment Threatens Supply in 2019

Global Demand for Bladder Cancer Treatment Threatens Supply in 2019

TICE BCG is indicated for the treatment and prophylaxis of carcinoma in situ of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection.

Smoking Associated With Worse Bladder Cancer Outcomes

Smoking Associated With Worse Bladder Cancer Outcomes

Smokers had poorer response to cisplatin-based neoadjuvant chemotherapy, higher recurrence risk.

Post-Cystectomy Short-Term Complications Not Hiked by NAC

Post-Cystectomy Short-Term Complications Not Hiked by NAC

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Researchers found no significant difference in 30-day postoperative complications between patients who received neoadjuvant chemotherapy and those who did not.

Neoadjuvant Chemotherapy for MIBC Ups Disease-Free Survival

Neoadjuvant Chemotherapy for MIBC Ups Disease-Free Survival

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Patients with muscle-invasive bladder cancer had a 22% decreased risk of disease progression if they received neoadjuvant rather than adjuvant chemotherapy, a study found.

Noninvasive Diagnostic Imaging Accurately IDs Bladder Cancer

Noninvasive Diagnostic Imaging Accurately IDs Bladder Cancer

Method evaluating cells collected from urine shows 94% diagnostic accuracy.

Post-Cystectomy Readmission Predictors Identified

Post-Cystectomy Readmission Predictors Identified

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Overweight and obesity, diabetes, and postoperative complications increase the likelihood of being readmitted within 30 days of hospital discharge among radical cystectomy patients.

Bladder Health Month: An Interview With Brian Stork, MD

Bladder Health Month: An Interview With Brian Stork, MD

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The goal of bladder health month is to encourage individuals to engage in dialogue with their healthcare providers about their symptoms and to empower them to actively participate in their care.

AKI Risk High in Cancer Patients Receiving Systemic Therapy

AKI Risk High in Cancer Patients Receiving Systemic Therapy

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In a study, nearly 1 in 10 cancer patients on systemic therapy experienced an episode of acute kidney injury.

Bladder Cancer Immunotherapy May Change Urologic Practice

Bladder Cancer Immunotherapy May Change Urologic Practice

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Promising results from clinical trials could encourage urologists to offer immunotherapy to their bladder cancer patients.

Mitomycin Gel Granted Breakthrough Status for Urothelial Cancer

Mitomycin Gel Granted Breakthrough Status for Urothelial Cancer

UGN-1 is an investigational formulation of mitomycin, delivered to patients using standard intravesical catheters.

Treating Bladder Cancer Ups Survival in Sicker Older Patients

Treating Bladder Cancer Ups Survival in Sicker Older Patients

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Older patients benefit from treatment of superficial bladder cancer even if they have multiple chronic conditions, a new study suggests.

Bladder Cancer Risk Not Lowered With Androgen Deprivation

Bladder Cancer Risk Not Lowered With Androgen Deprivation

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In a study, men with prostate cancer who received androgen deprivation therapy did not have a lower subsequent risk of developing bladder cancer.

The Role of Enhanced Cystoscopy in Patients With Nonmuscle-Invasive Bladder Cancer

The Role of Enhanced Cystoscopy in Patients With Nonmuscle-Invasive Bladder Cancer

Enhanced cystoscopy at the time of cystectomy and in the outpatient surveillance setting increases detection of high-grade NMIBC.

Diabetes Population Has Higher Incidences of Bladder, Kidney Cancer

Diabetes Population Has Higher Incidences of Bladder, Kidney Cancer

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Finnish study of individuals with type 2 diabetes reveals a 17% and 42% higher incidence of bladder and kidney cancer, respectively, compared with the general population.

Neoadjuvant Dose-Dense MVAC May Improve Post-Cystectomy Outcomes

Neoadjuvant Dose-Dense MVAC May Improve Post-Cystectomy Outcomes

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Higher rates of complete response observed in MIBC patients who received a dose-dense combination of methotrexate, vinblastine, doxorubicin, and cisplatin rather than the standard gemcitabine plus cisplatin or carboplatin.

Adjuvant Gemcitabine, BCG for NMIBC Offer Similar Efficacy

Adjuvant Gemcitabine, BCG for NMIBC Offer Similar Efficacy

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New meta-analysis shows adjuvant intravesical gemcitabine and bacillus Calmette-Guérin do not differ significantly with respect to risk of recurrence, progression, and adverse events.

Female Sex Ups Radical Cystectomy Surgical Site Infection Risk

Female Sex Ups Radical Cystectomy Surgical Site Infection Risk

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Among patients undergoing radical cystectomy, female sex is independently associated with a 21% increased odds of surgical site infections compared with male sex.

Bladder Cancer Survival Better Among Married Patients

Bladder Cancer Survival Better Among Married Patients

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Widowed patients with bladder urothelial carcinoma have the worst 5-year cancer-specific survival rates among unmarried patients.

Urine Cytology May Not Improve Hematuria Evaluation for Bladder Cancer

Urine Cytology May Not Improve Hematuria Evaluation for Bladder Cancer

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British investigators concluded that urine cytology misses a significant number of muscle-invasive bladder cancers.

Overnight Saline Irrigation May Prevent Early NMIBC Recurrence

Overnight Saline Irrigation May Prevent Early NMIBC Recurrence

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Recurrence rate was 26.4% among patients who had overnight continuous saline irrigation following transurethral resection of bladder tumor vs 38.2% among those who did not.

Keytruda, Tecentriq Labeling Updated to Limit Use in Urothelial Cancer

Keytruda, Tecentriq Labeling Updated to Limit Use in Urothelial Cancer

The updates come after the Agency made the decision to limit the use of these agents as monotherapy in patients with metastatic urothelial cancer who have not received prior therapy and who have low expression of the protein programmed death ligand 1 (PD-L1).

Radical Cystectomy Offers Better Survival vs Trimodal Therapy

Radical Cystectomy Offers Better Survival vs Trimodal Therapy

Bladder preservation for MIBC is associated with a higher mortality rate and greater costs compared with radical cystectomy.

Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes

Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes

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In a randomized study, patients who underwent robotic-assisted and open radical cystectomy had similar 2-year progression survival rates.

Gender Difference in Survival Seen After Radical Cystectomy

Gender Difference in Survival Seen After Radical Cystectomy

Females have worse disease-free, cancer-specific, overall survival versus males with bladder cancer.

Robotics Involved in Most Urologic Cancer Surgeries

Robotics Involved in Most Urologic Cancer Surgeries

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In 2015, 69% of surgeries for prostate, bladder, and kidney cancer were performed with robotic assistance, a new meta-analysis shows.

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