Chronic Kidney Disease

Faster eGFR Decline Predicts Worse Outcomes in CKD Patients with AF

Faster eGFR Decline Predicts Worse Outcomes in CKD Patients with AF

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Longitudinal renal function trajectories may enable more individualized prediction of adverse outcomes, researchers conclude.

CKD Progression Tied to Low Potassium Excretion

CKD Progression Tied to Low Potassium Excretion

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In a study of patients with chronic kidney disease (CKD), those in the lowest vs highest quartile of 24-hour urinary potassium excretion had a 3-fold increased risk of CKD progression.

Kidney Stones Predict Osteoporotic Fracture in CKD

Kidney Stones Predict Osteoporotic Fracture in CKD

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In a new study of patients with chronic kidney disease, the presence of kidney stones, compared with their absence, was significantly associated with a 2.3-fold increased risk of osteoporotic fracture.

Improper Patient Selection for NSS May Increase CKD Risk

Improper Patient Selection for NSS May Increase CKD Risk

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In a study, chronic kidney disease was nearly twice as likely to develop in patients who had post-operative complications following nephron-sparing surgery.

Higher Glucose Levels At Dialysis Transition Increase Mortality Risk

Higher Glucose Levels At Dialysis Transition Increase Mortality Risk

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New findings suggest that diabetic patients with advanced chronic kidney disease may need different glucose control strategies depending on whether or not they are transitioning to dialysis.

Kidney Damage Tied to Proton Pump Inhibitors

Kidney Damage Tied to Proton Pump Inhibitors

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A large retrospective study found that the acid-suppressing medications increase the risk of acute kidney injury and chronic kidney disease.

Statin Use Common in Veterans on Maintenance Dialysis

Statin Use Common in Veterans on Maintenance Dialysis

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More than half of US veterans with dialysis-dependent chronic kidney disease are statin medications, about one-third receiving high doses of the drugs.

Kidney Damage in Younger Adults Tied to NSAID Use

Kidney Damage in Younger Adults Tied to NSAID Use

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Individuals taking more than 7 defined daily doses of NSAIDs each month had 20% greater risks of acute kidney injury and chronic kidney disease than those taking none.

Burden, Access and Disparities in Kidney Disease

Burden, Access and Disparities in Kidney Disease

Socially disadvantaged individuals experience a disproportionate burden of kidney disease worldwide.

Sustained Normokalemia to Enable RAAS Inhibition Beneficial in CKD

Sustained Normokalemia to Enable RAAS Inhibition Beneficial in CKD

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New model predicts that maintenance of normal potassium levels in CKD patients to optimize use of renin-angiotensin-aldosterone inhibitors can delay progression to ESRD and prolong survival.

Exome Sequencing Opens a New Chapter in CKD

Exome Sequencing Opens a New Chapter in CKD

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Study results point to a future when whole exome sequencing will be the method of choice for identifying genetic causes of CKD.

Optimal CKD Follow-Up Intervals Proposed

Optimal CKD Follow-Up Intervals Proposed

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Longer follow-up intervals than recommended in current guidelines may be appropriate.

Statins Underused by Adults With Chronic Kidney Disease

Statins Underused by Adults With Chronic Kidney Disease

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Although a 2013 guideline recommended statin use to more than 65% of adults with CKD, only about 36% of adults with CKD were taking a statin in 2011-2014.

Personalized Tx May Extend Life in CKD With Small Renal Tumors

Personalized Tx May Extend Life in CKD With Small Renal Tumors

Routine partial nephrectomy yielded longest life expectancy in patients with normal renal function.

Novel Albuminuria Endpoints May Improve CKD Progression Trials

Novel Albuminuria Endpoints May Improve CKD Progression Trials

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Two companion meta-analyses show that early changes in albuminuria can predict the risk for end-stage renal disease.

New Predictor of In-Hospital Acute Kidney Injury Identified

New Predictor of In-Hospital Acute Kidney Injury Identified

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Elevated calcium-phosphate product at hospital admission is associated with an increased risk of acute kidney injury.

Spironolactone Helps HF Patients With CKD, But Ups Hyperkalemia Risk

Spironolactone Helps HF Patients With CKD, But Ups Hyperkalemia Risk

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Spironolactone improved cardiovascular outcomes in heart failure patients with chronic kidney disease, but increased their risk of hyperkalemia.

Sugar-Sweetened Drinks Linked to Chronic Kidney Disease Risk

Sugar-Sweetened Drinks Linked to Chronic Kidney Disease Risk

Odds of CKD up with beverage pattern consisting of higher intake of sweetened soda, fruit drinks, water

Exome Sequencing Zeroes in on Genetic Diagnoses in CKD

Exome Sequencing Zeroes in on Genetic Diagnoses in CKD

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In a study of patients with chronic kidney disease, the technique for sequencing protein-coding genes yielded a genetic diagnosis in 9.3% of cases.

Chronic Kidney Disease Linked to Hepatitis B

Chronic Kidney Disease Linked to Hepatitis B

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In a study of nearly 300,000 South Koreans, individuals who tested positive for hepatitis B virus had an 11% higher risk of CKD.

Chronic Kidney Disease Progression Risk Lower in Women

Chronic Kidney Disease Progression Risk Lower in Women

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In a study of adults with mild-to-moderate chronic kidney disease, women had a significant 28% decreased risk of end-stage renal disease compared with men.

Multiple Comorbidities in CKD Patients Up Dialysis Initiation Risk

Multiple Comorbidities in CKD Patients Up Dialysis Initiation Risk

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Patients with stage 3-5 chronic kidney disease who have 3 or more comorbidities are 3 times more likely to start dialysis than those with no comorbidities, a study found.

Care for Chronic Kidney Disease Varies Across VA Facilities

Care for Chronic Kidney Disease Varies Across VA Facilities

Findings observed for veterans with diabetes and concomitant chronic kidney disease

Chronic Kidney Disease Burden Increasing in the US

Chronic Kidney Disease Burden Increasing in the US

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Study implicates growing prevalence of metabolic and dietary risk factors as important contributors to increases in CKD burden.

Home-Based Intervention Helpful for Disadvantaged CKD Patients

Home-Based Intervention Helpful for Disadvantaged CKD Patients

Rural Zuni Indians with kidney disease had improved activation in their own health and health care

Acute Kidney Injury Increases Risks for CKD, ESRD, and Mortality

Acute Kidney Injury Increases Risks for CKD, ESRD, and Mortality

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In a meta-analysis, the risks for premature death nearly doubled, CKD nearly tripled, and ESRD nearly quintupled after an episode of acute kidney injury.

ESA Use for Non-Dialysis CKD Anemia in Decline

ESA Use for Non-Dialysis CKD Anemia in Decline

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Use of erythropoiesis-stimulating agents to treat anemia in patients with non-dialysis-dependent chronic kidney disease has been decreasing since the October 2009 publication of TREAT results.

New Cholesterol Guidelines Consider CKD 'Risk-Enhancing'

New Cholesterol Guidelines Consider CKD 'Risk-Enhancing'

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In their 2018 cholesterol guidelines, the American Heart Association and American College of Cardiology recommend individualized risk and treatment options.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol use is not associated with renal function decline among those with newly diagnosed gout.

Novel Acid-Binding Drug Effective for Metabolic Acidosis in CKD

Novel Acid-Binding Drug Effective for Metabolic Acidosis in CKD

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A polymer that binds to hydrochloric acid in the GI tract and does not enter the systemic circulation significantly improved serum bicarbonate levels compared with placebo.

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